Fig. 4: BBB impairment and JUN upregulation in ASD. | Translational Psychiatry

Fig. 4: BBB impairment and JUN upregulation in ASD.

From: Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis

Fig. 4

A Schematic diagram of modeling a mouse model of ASD with maternal immune activation. Embryonic day 12.5 (E12.5 d). B The movement trajectories in the open field test (OFT) (n = 6). C Time spent in the corner and center of OFT experitment (n = 6). D The number of marbles buried in the Marble buried experiment(n = 6). E Social time in three-chamber social interaction test (n = 6). F Relative protein levels of ZO-1 and occludin in control and poly(I: C) group (n = 6). G Relative protein levels of IBA1 and JUN in control and poly(I: C) group (n = 6). Scale bars, 20 μm. Scale bars, 20 μm. Error bars indicate as means ± SD, *P < 0.05, **P < 0.01, ***P < 0.001 compared with control and poly(I: C) group, unpaired t-test.

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