Fig. 6: IL-6 upregulate the JUN/MMP-9 pathway. | Translational Psychiatry

Fig. 6: IL-6 upregulate the JUN/MMP-9 pathway.

From: Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis

Fig. 6

A Ventricular administration of JNK inhibitor for 3 days significantly altered the protein expression levels of JUN and MMP-9 across four experimental groups (n = 6). B The mRNA expression of JUN and MMP-9 was assessed by RT-qPCR in BV-2 cells after 10 ng/ml IL-6 or 5 μM/ml JNK inhibitor for 24 h (n = 4). Scale bars, 20 μm. Error bars indicate as means ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, One-way ANOVA.

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