Fig. 7: Differential gene expression analysis in Chd8-inKO mice. | Translational Psychiatry

Fig. 7: Differential gene expression analysis in Chd8-inKO mice.

From: CHD8 adulthood microglial knockdown in C57BL6 mice induces behavioral, morphological, and transcriptional changes in a sex-dependent manner

Fig. 7

RNA-Seq analysis of hippocampal samples from Chd8-inKO male and female mice. Volcano plots highlight minor transcriptional alterations in Chd8-inKO a males and b females. c, d Gene Set Enrichment Analysis (GSEA) detects enrichment for genes within the Hedgehog and Wnt/Beta-catenin pathways that are upregulated specifically in males c but not changed in females d.

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