Fig. 4: Screening of overlapping differential proteins and their mediating effects on AD risk. | Translational Psychiatry

Fig. 4: Screening of overlapping differential proteins and their mediating effects on AD risk.

From: The blood lipidome fatty acid profile predicts the disease risk and clinical phenotypes of Alzheimer’s disease: associations from two prospective cohort studies

Fig. 4

Volcano plots of proteins associated with AD incidence A and FAS B. The Venn diagram illustrated the differential proteins among the four groups. Group A: proteins positively associated with AD incidence; Group B: proteins negatively associated with AD incidence; Group C: proteins negatively associated with higher FAS; Group D: proteins positively associated with higher FAS. Four overlapping proteins (adgrg1, chi3l1, gdf15, and rbfox3) were shared between Groups A and D, indicating significant relevance to both AD incidence and higher FAS. C. Mediation analyses indicated that the relationship between FAS and AD risk was mediated by screening differential proteins D. FAS Fatty acid score, IE indirect effect.

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