Fig. 3: Neurotransmitter receptor groups on immune cells and their interactions with antidepressants.
From: Modulation of neuroimmune cytokine networks by antidepressants: implications in mood regulation
Schematic representation of neurotransmitter receptors expressed on immune cells, including serotonin (5-HT), dopamine (DA), norepinephrine (NE), gamma-aminobutyric acid (GABA), acetylcholine (ACh), and histamine (H1). Different classes of antidepressants interact with these receptors, modulating immune function: SARIs (mast cells, B-cells), SSRIs (natural killer cells, dendritic cells, eosinophils), SNRIs (macrophages, dendritic cells), and NASSAs (monocytes). These interactions contribute to neuroimmune regulation, influencing inflammatory pathways and immune cell activity. SARIs serotonin antagonist and reuptake inhibitors, SSRIs selective serotonin reuptake inhibitors, SNRIs serotonin-norepinephrine reuptake inhibitors, NASSAs noradrenergic and specific serotonergic antidepressants, GABA(A)R/GABA(B)R gamma-aminobutyric acid receptors type A and B, AChR acetylcholine receptor. Created with BioRender.com.
