Fig. 2: Global, edge-wise, network-wise and PFC-specific resting-state FC differences between SSCE and CON groups. | Translational Psychiatry

Fig. 2: Global, edge-wise, network-wise and PFC-specific resting-state FC differences between SSCE and CON groups.

From: Multi-connectomics underpin emotional dysfunction in mouse exposed to simulated space composite environment

Fig. 2

a To calculate the pairwise FC, 160 regions of interest (ROIs) were defined based on the TMBTA reference, with 80 in each hemisphere. Pearson correlations were calculated between the BOLD time series of all unique ROI pairs. A group-averaged region-wise FC matrix for the 2-week CON group is shown, reordered by network assignments. b The FC matrix is represented as a weighted network graph, with ROIs as nodes and their pairwise correlations as edges. For clarity, only the strongest 10% of edges are shown, with edge thickness and opacity scaling with the correlation value and node radius scaling with the weighted degree (the weighted sum of all edges connected to the node). c The regional functional connectivity strength is violin plotted and also projected on the brain surface for each group. Each dot represents a single region. Asterisks indicate the significance from paired t-tests after adjusting for multiple comparisons (*p < 0.05; ** p < 0.01; ***p < 0.001). d Edge-wise FC differences between SSCE and CON groups are represented with graph for both 2-week (top) and 4-week (bottom) modeling. Edge thickness and opacity scale with the effect size (red: SSCE > CON, blue: SSCE < CON); node radius scales with the weighted sum of effect size. For visualization, a statistical threshold of p < 0.001 is applied. e The LME model was performed to illustrate the interaction of condition (SSCE or CON) × time on FC. Chord diagram highlights edges with the significant interaction of modeling time and group (p < 0.001). f Network-wise FC differences between SSCE and CON groups for both 2-week (left) and 4-week (right) modeling are represented in matrix form. Significant network pairs are further highlighted in a chord diagram (red: SSCE > CON, blue: SSCE < CON, * p < 0.05). g The interaction of condition × timing on FC is visualized at the network level (* p < 0.05). h PFC-specific FC differences between SSCE and CON groups for both 2-week (top) and 4-week (bottom) modeling are represented with graphs. Edge thickness and opacity scale with the effect size (red: SSCE > CON, blue: SSCE < CON); node radius scales with the weighted sum of effect size. i PFC voxel-wise FC strength is displayed in raincloud plots and sagittal brain view for each group. Each dot represents a voxel within the PFC. Asterisks indicate the significance of paired t-tests after multiple comparisons adjustments (*p < 0.05; ** p < 0.01; ***p < 0.001).

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