Fig. 8: Association between differences in PL-specific functional profiles and gene expression profiles. | Translational Psychiatry

Fig. 8: Association between differences in PL-specific functional profiles and gene expression profiles.

From: Multi-connectomics underpin emotional dysfunction in mouse exposed to simulated space composite environment

Fig. 8

a Normalized gene expression levels across 157 ROIs. b Brain surface projections of effect size values for the 2-week and 4-week comparison pairs (left) and gene expression levels. c Number of genes significantly correlated with the 2-week and 4-week effect size maps. d Significant genes are ranked in descending order according to their correlation coefficients. Scatter plots illustrate representative correlations between effect size values and gene expression levels. e GO enrichment analysis of genes significantly correlated with differences in PL-specific functional profiles for the 2-week (left) and 4-week (right) comparison pairs. Enrichment in cellular components (orange), biological processes (blue) and molecular functions (green) is shown. Note that, q value represents the FDR-corrected p value. The color of the circle represents the enrichment score of each term. The size of the circle indicates the number of genes significantly enriched in each term.

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