Fig. 1: Manhattan plot and genomic regional plots for the gene-by-environment (G×E) GWAS between SNPs and blood MCP-1 levels for AD in the FHS. | Translational Psychiatry

Fig. 1: Manhattan plot and genomic regional plots for the gene-by-environment (G×E) GWAS between SNPs and blood MCP-1 levels for AD in the FHS.

From: The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci

Fig. 1

G×E GWAS analyses between MCP-1 (log-transformed) and common SNPs (MAF > 5%) for AD were performed using logistic regression adjusted for age, sex, years of education and PCs. A Manhattan plot is presented with the following highlighted SNPs: NAV3 rs696468 and UNC5C rs72659964 (A). The genomic regional plots present the locations, LD information, p values, recombination rates, nearby gene information and DNA methylation CpG sites associated with the tagged SNPs of NAV3 (B) and UNC5C (C).

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