Fig. 2: Stratified genotype analysis for the effect of blood MCP-1 levels on incident AD using Cox proportional hazard regression models in the FHS. | Translational Psychiatry

Fig. 2: Stratified genotype analysis for the effect of blood MCP-1 levels on incident AD using Cox proportional hazard regression models in the FHS.

From: The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci

Fig. 2

The FHS Gen2 participants were divided into different genotype groups: NAV3\(-\) (rs696468 CC, n = 2189) and NAV3\(+\) (rs696468 CT/TT, n = 695) or UNC5C\(-\) (rs72659964 AA, n = 2552) and UNC5C\(+\) (rs72659964 AT/TT, n = 332). Within each genotype group, individuals were further divided into low and high MCP-1 groups based on different cutoff MCP-1 levels: <50% and ≥ 50%, <60% and ≥ 60%, and <75% and ≥ 75%. Cox proportional hazards regression analyses were applied to examine the effect of different levels of MCP-1 on the incidence of AD within each genotype group after adjusting for age, sex, years of education and PCs. HRs and p values are illustrated (A and B). In addition, participants were divided into low and high groups based on the median MCP-1 concentration. Kaplan‒Meier survival plots were then used to show the probability of AD-free survival within each genotype group. The differences between the low vs. high groups for each genotype are illustrated with p values (C and D).

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