Fig. 3: Stratified genotype analysis of blood MCP-1 levels (log-transformed) on the plasma AD biomarkers using linear regression models in the FHS. | Translational Psychiatry

Fig. 3: Stratified genotype analysis of blood MCP-1 levels (log-transformed) on the plasma AD biomarkers using linear regression models in the FHS.

From: The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci

Fig. 3

The FHS Gen2 participants were divided into subgroups based on the genotype of NAV3 rs696468 CC (n = 1467 for pTau181) and NAV3 rs696468 CT/TT (n = 465 for pTau181) (A); UNC5C rs72659964 AA (n = 1692 for pTau181) and UNC5C rs72659964 AT/TT (n = 240 for pTau181) (B). The data on plasma levels of pTau181 (A and B), t-Tau (C and D), Aβ40 (E and F) and Aβ42 (G and H) were used. The linear regression models were performed between the AD biomarkers (log-transformed) and continuous blood MCP-1 concentration (log-transformed) after adjusting for age, sex, years of education and PCs. Bar charts showing regression estimates (β)±se of the MCP-1 effect for each biomarker within each genotype with p values.

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