Fig. 6: Working model of CDYL’s role in fear memory and its regulatory mechanism.
From: Activity-dependent phosphorylation of CDYL by CDK5 regulates fear memory in mice
This model illustrates how CDYL contributes to fear memory formation. CDYL is phosphorylated by CDK5 in response to neural activity, which enhances TRIM32-mediated ubiquitination and degradation of CDYL in the hippocampus. This process contributes to the strengthening of fear memory. The introduction of an interfering peptide that specifically blocks CDYL phosphorylation at Ser147 effectively reduces fear memory in mice.
