Fig. 4: Associations between haploinsufficiency, sleep and cognition.
From: The interplay between genomic copy number variants, sleep, and cognition in the general population
a, b represent the fitted curves of the quadratic model associating CNVs measured by their sum of 1/LOEUF (for (a) deletions and (b) duplications) with self-reported sleep duration (dark line). The light line represents the GAM model. The dotted vertical line indicates the vertex of the parabola. c, d illustrates the results of the mediation analysis between the sum of LOEUF (for deleted and duplicated genes), sleep duration, and cognitive ability (*p-value < 2e−16). The Average Causal Mediation Effect effect was 0.005 × −0.129 = −0.0007 (p < 2e-16) for deletions and 0.002 × −0.146 = −0.0003 (p < 2e-16) for duplications. The proportion mediated was 3.8% for deletions and 4.5% for duplications.
