Table 2 Pre-treatment EEG metrics showing correlation with clinical outcomes, measured by improvements in cognitive performance scores, in Trial 1.

From: Novel electroencephalographic biomarkers for the prediction of responders to an experimental glutamatergic agent in patients with schizophrenia

Lead

Brain Location

Eeg Measure

Recording State

Outcome Measure

r

P-Value

Fz

central frontal

β/γ

photically driven

speed of processing

0.66

0.000025

O2

right occipital

beta

resting

attention-vigilance

0.49

0.00003

T5

left temporo-occipital

alpha

photically driven

composite cognitive score

0.43

0.00041

Fp2

right prefrontal

beta

photically driven

composite cognitive score

0.41

0.00063

F4

right frontal

PLE

resting

working memory

0.41

0.00071

ic4

N/A

beta5

resting

social cognition

0.38

0.0018

Fz

central frontal

alpha

photically driven

reasoning-problem solving

0.37

0.0021

F3

left fronto-temporal

PLE

resting

working memory

0.36

0.0034

ic4

N/A

beta3

resting

social cognition

0.34

0.0047

T6

right temporo-occipital

beta

photically driven

reasoning-problem solving

āˆ’0.33

0.0068

F8

right fronto-temporal

gamma1

resting

reasoning-problem solving

āˆ’0.33

0.0057

C4

right central

low beta

photically driven

social cognition

0.33

0.0067

T6

right temporo-occipital

PLE

resting

working memory

0.32

0.0082

F7

left fronto-temporal

low beta

photically driven

social cognition

0.32

0.0089

  1. See Methods for details. Electrode abbreviations as in Fig. 1A. ic, independent component.