Fig. 2: Untargeted metabolomics analysis revealed significant differences in gut microbiota metabolites between mice receiving fecal microbiota transplantation (FMT) from healthy controls and women with prenatal depression. | Translational Psychiatry

Fig. 2: Untargeted metabolomics analysis revealed significant differences in gut microbiota metabolites between mice receiving fecal microbiota transplantation (FMT) from healthy controls and women with prenatal depression.

From: Prenatal depression-associated gut microbiota induces depressive-like behaviors and hippocampal neuroinflammation in germ-free mice

Fig. 2

A Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) of fecal metabolic profiles in two groups. B Volcano plot showed differential metabolites in the gut microbiota between two groups. C Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of differential metabolites. D Spearman correlation analysis of differential genera with differential metabolites. HC-FMT, mice receiving FMT from women with healthy control (n = 7); PD-FMT, mice receiving FMT from women with prenatal depression (n = 7); metab_4091, PS(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); metab_5356, PS(20:3(8Z,11Z,14Z)/18:3(9Z,12Z,15Z)); data are shown as mean ± SEM; *, p < 0.05; **, p < 0.01; differences are assessed by Student’s t-test.

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