Fig. 3: Snai2−/− mice exhibit behavioral abnormalities and decreased neuronal activity in their brains. | Translational Psychiatry

Fig. 3: Snai2−/− mice exhibit behavioral abnormalities and decreased neuronal activity in their brains.

From: Developmental arrest of astrocyte lineage in Snai2 deletion mice: implication for the intellectual disability in patients with Waardenburg syndrome

Fig. 3

A The bar charts showing results from the OF test done with Snai2+/+, Snai2+/−, and Snai2−/− mice (Snai2+/+ n = 32, Snai2+/− n = 32, Snai2−/− n = 18). B The line chart showing results from BM test done with Snai2+/+, Snai2+/−, and Snai2−/− mice (Snai2+/+ n = 10, Snai2+/− n = 10, Snai2−/− n = 10). C The bar charts showing results from the NOR test done with Snai2+/+, Snai2+/−, and Snai2−/− mice (Snai2 +/+ n = 32, Snai2+/− n = 32, Snai2−/− n = 18). D The line chart showing the results from the NB test done with Snai2+/+, Snai2+/−, and Snai2−/− mice (Snai2+/+ n = 32, Snai2+/− n = 32, Snai2−/− n = 20). E Representative images of regional brain glucose metabolism measured by 18F-FDG PET in Snai2+/+, Snai2+/−, and Snai2−/− mice. The heat maps show differential glucose uptake in various brain regions of mice. F Standardized uptake value (SUV) of 18F-FDG in various brain regions of Snai2+/+, Snai2+/−, and Snai2−/− mice (n = 6 per group). Data are presented as mean ± SEM in (A–D), and (F). Each group has an equal number of males and females. Statistical analysis was done with one-way ANOVA followed by post-hoc Tukey’s multiple comparisons. ns=not significant, *p < 0.05, **p < 0.01, ***p < 0.001.

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