Fig. 3: Bidirectional modulation of CB1R activity in NAc has the opposite effect on anxiety. | Translational Psychiatry

Fig. 3: Bidirectional modulation of CB1R activity in NAc has the opposite effect on anxiety.

From: Cannabinoid CB1 receptor in dopaminergic circuit from ventral tegmental area to nucleus accumbens links trait anxiety with reward learning

Fig. 3

A. Schematic diagram of cannula implantation and experimental scheme of anxiety tests. n = 8 mice for each group. B. Representative image of NAc-implantation sites and the placements of bilateral optic fiber tips. Scale bar, 100 μm. C-G. Representative traces and statistics in OFT. H-L. Traces and statistics representing mice performance in EPM. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ns for no significance.

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