Fig. 4: Blocking CB1R in NAc leads to reward learning deficit. | Translational Psychiatry

Fig. 4: Blocking CB1R in NAc leads to reward learning deficit.

From: Cannabinoid CB1 receptor in dopaminergic circuit from ventral tegmental area to nucleus accumbens links trait anxiety with reward learning

Fig. 4

A. The timeline of experimental scheme and diagram for cannula implantation and ethanol-mediated CPP. Vehicle group (n = 7), AM-251 group (n = 8), WIN55,212-2 group (n = 8). B. Representative traces and behavioral performance result of pre/post-training test. C-D. Mean time spent in the conditioned side and preference score during the post-training test. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ns for no significance.

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