Fig. 6: CB1R knockout in VTADA neurons reduces the reward learning ability. | Translational Psychiatry

Fig. 6: CB1R knockout in VTADA neurons reduces the reward learning ability.

From: Cannabinoid CB1 receptor in dopaminergic circuit from ventral tegmental area to nucleus accumbens links trait anxiety with reward learning

Fig. 6

A. Schematic of viral injection and ethanol-mediated CPP paradigm. WT group (n = 9), CB1R−/− group (n = 6). B. Immunofluorescent analysis of viral expression in VTA. Red channel showed the mCherry expression. Green channel exhibited the staining of anti-TH. Scale bar, 100 μm. C. The quantitative analysis of Venn diagram shows the co-expression level of mCherry with TH in SNc. D. Locations of the viral injection for all animals analyzed in WT and CB1R−/− groups. E. Representative traces and behavioral performance result of pre/post-training test. F-G. Mean time spent in the conditioned side and preference score during the post-training test. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ns for no significance.

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