Fig. 2: Bioinformatics analysis of mPFC DEGs. | Translational Psychiatry

Fig. 2: Bioinformatics analysis of mPFC DEGs.

From: The impact of musical intervention during fetal and infant stages on social behavior and neurodevelopment in mice

Fig. 2

A. Heatmap showing cluster analysis of 1283 mRNAs in the mPFC. B. Volcano plots of DEGs in the three music groups, with labeled genes validated by qPCR. C. Venn diagram of DEGs in the three music groups. D. Enrichment heatmap of the top 20 pathways associated with DEGs in the mPFC. E. Similarity and association analysis within and between clusters of the top 20 enriched pathways in the mPFC. F. Relative mRNA levels of the Galr3, Pomc and Gh genes involved in the Neuroactive ligand-receptor interaction pathway. G. Relative mRNA levels of the Avp, Chrnb4 and Ffar3 genes involved in the regulation of transmission of nerve impulse pathway. H. Relative mRNA 12levels of the Chrna3, Chrm5 and Chrna10 genes in the synaptic signaling pathway. I. Relative mRNA levels of the Slc6a3, Drd4 and Th genes in the synaptic transmission, dopaminergic pathway. (n = 6; one-way ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; values are the means ± SEM).

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