Table 1 Characterization of in vivo metabolites of Tetrahydroberberrubine 1-3 by HPLC/ESI-IT-TOF-MS.

From: Author Correction: Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy

No.

RT (min)

Formula

HR-MS [M+H]+

(+)ESI-MSn(m/z)

Metabolites reaction

Plasma

Urine

Feces

Measured

Predicted

Δ (ppm)

1*

6.99

C19H19NO4

326.1394

326.1387

2.15

MS2[326]: 80

none

++

++

++

2

5.50

C20H18NO4

337.1340

337.1309

9.19

MS2[337]: 312, 80

+CH3-4H

—

—

++

3

32.12

C20H21NO4

338.1328

338.1387

9.20

MS2[338]: 321, 312

+CH3

++

++

+

  1. *Identified by comparing with reference standards;
  2. ++, detected at high abundance; +, detected; —, not detected.
  3. aConfirmed by enzyme hydrolysis.
  4. The original article has been corrected.
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