Table 1 Antiviral activity and cytotoxicity of the 23 compounds on BHK-21 cells were evaluated by EC50 and CC50, and the compounds were ranked according to their SIs (CC50/EC50) in the table.
Name | EC50 (µM) Mean ± SD | CC50 (µM) Mean ± SD | SI | Name | EC50 (µM) Mean ± SD | CC50 (µM) Mean ± SD | SI |
|---|---|---|---|---|---|---|---|
Salvianolic acid A | 1.2 ± 0.7 | 375.0 ± 106.0 | 312.50 | Sanggenon C | 13.0 ± 5.7 | 34.4 ± 23.5 | 2.65 |
Chebullinic acid | 2.1 ± 1.9 | 241.9 ± 11.5 | 114.76 | Embelin | 9.8 ± 3.9 | 22.0 ± 4.5 | 2.24 |
Tannic acid | 3.0 ± 1.1 | 180.4 ± 60.4 | 60.13 | Daunorubicin (hydrochloride) | 3.3 ± 0.6 | 7.2 ± 3.7 | 2.18 |
Punicalagin | 5.6 ± 0.2 | 300 ± 212.0 | 53.57 | Doxorubicin (hydrochloride) | 2.0 ± 1.1 | 3.9 ± 3.7 | 1.95 |
2-Methoxyestrone | 15.0 ± 1.7 | 455.0 ± 7.1 | 30.33 | Hypericin | 1.9 ± 1.6 | 1.7 ± 2.0 | 0.89 |
4’,5-Dihydroxyflavone | 16.0 ± 7.4 | 150 ± 16.1 | 9.38 | Garcinone | >50 | 26.5 ± 2.6 | – |
Isoginkgetin | 10.3 ± 3.8 | 96.0 ± 76.0 | 9.32 | 5-Hydroxyflavone | >50 | >450.0 | – |
Emodin | 17.4 ± 1.1 | 126.0 ± 7.5 | 7.24 | Vanillyl alcohol | >50 | 351.2 ± 171.0 | – |
7-Ethylcamptothecin | 0.2 ± 0.1 | 1.1 ± 0.7 | 5.50 | Coumarin 6 | >50 | >450.0 | – |
Deoxycorticosterone | 37.1 ± 17.0 | 204.0 ± 98.0 | 5.50 | Skimmin | >50 | 397.0 ± 55.0 | – |
Demethylzeylasteral | 3.6 ± 0.6 | 19.2 ± 0.1 | 5.33 | Pyrrole-2-carboxylic acid | >50 | 79.4 ± 24.6 | – |
Gambogic acid | 0.8 ± 0.1 | 2.6 ± 0.7 | 3.25 | Ribavirin | 2.3 ± 1.3 | 29.7 ± 11.4 | 12.90 |
