Table 2 Characteristics of the included studies.
Authors, year, country | Study type (level of evidence) - Risk of bias | Population Characteristics | Sites involved | Groups | Concentrates preparation | Outcomes Measured | Pain results | Favoured protocol | Funding |
|---|---|---|---|---|---|---|---|---|---|
Yari et al., [42], Iran | RCT (II) - Moderate | Sites: 62 Males: 28 Females: 34 Age: 22.5 ± 3.2 | Mandibular Third Molars | Sites: 15 Protocol: Control Sites: 15 Protocol: A-PRF Sites: 16 Protocol: A-PRF+ Sites: 16 Protocol: L-PRF | L-PRF: 2800 rpm x 12 min (TD 4, HereXi Instruments Inc.) A-PRF: 1500 rpm x 14 min (TD 4, HereXi Instruments Inc.) A-PRF + : 1300 rpm x 8 min (TD 4, HereXi Instruments Inc.) | soft tissue healing, pain, analgesic use, trismus, facial swelling, and alveolar osteitis. | VAS Scores at 1, 2 and 3 days: Control: 48 ± 11.86, 36.13 ± 7.72, 17.38 ± 7.72 L-PRF: 38.13 ± 5.43, 30.31 ± 3.04, 10.63 ± 4.42 A-PRF: 34.38 ± 5.25, 23.69 ± 7.72, 7.88 ± 4.29 A-PRF + : 34.69 ± 5.62, 25 ± 6.58, 9.13 ± 4.36 | A-PRF and A-PRF + | None |
Riaz et al., [41], India | Cohort Study (III) - High | Sites: 20 Males: 3 Females: 7 Age: 26.5 (18– 35) | Mandibular Third Molars | Sites: 5 Protocol: PRF Sites: 5 Protocol: A-PRF Sites: 10 Protocol: Control | A-PRF: 1500 rpm x 14 min (REMI C-852, Remielektrotechnik Ltd, Vasai, India) PRF: 3000 rpm x 10 min (REMI C-852, Remielektrotechnik Ltd, Vasai, India) | Pain, swelling, and mouth opening (VAS for pain, flexible tape for swelling, interincisal distance for mouth opening). | VAS Scores at 1, 3 and 7 days: PRF control: 2.6, 2.0, 1.6 PRF: 2.4, 1.4, 0.6 A-PRF control: 3.0, 2.4, 1.4 A-PRF: 2.6, 1.4, 0.4 | A-PRF | None |
Verma et al., [40], India | Cohort Study (III) - High | Sites: 40 Males: 13 Females: 7 Age: (21–48) | Mandibular Third Molars | Sites: 20 Protocol: PRF Sites: 20 Protocol: PRP | NR | Pain using 1-10 rating communicated by patient, trismus, and swelling | Pain scores mean of 15 days: PRF: 3.83 ± 0.456 PRP: 3.42 ± 0.536 | none | NR |
Ustaoğlu et al., [39], Turkey | RCT (II) - Low | Sites: 57 Males: 28 Females: 29 Age: 35.4 ± 5.6 | Anterior and Premolar teeth | Sites: 19 Protocol: Control Sites: 19 Protocol: T-PRF Sites: 19 Protocol: L-PRF | L-PRF: 2700 rpm x 12 min (Intra-Spin System, L-PRF kit, Intra-Lock, Boca-Raton, FL, USA) T-PRF: 2800 rpm x 12 min (Intra-Spin System, L-PRF kit, Intra-Lock, Boca-Raton, FL, USA) | Pain VAS and the number of analgesics taken for 3 days post-extraction. Landry Wound Healing Index (LWHI) and H2O2 epithelization test. Intraoral periapical radiographs were obtained and analyzed using fractal dimension analysis to assess bone healing. | VAS scores at 1, 2 and 3 days: Control: 5.11 ± 1.6, 1.01 ± 1.44, 0 L-PRF: 3.3 ± 2.07, 0.48 ± 0.92, 0 T-PRF: 3.29 ± 1.85, 0.47 ± 0.62, 0 | none | None |
Bhujbal et al., [38], India | Cohort Study (III) - Moderate | Sites: 40 Males: 7 Females: 13 Age: 26 ± 6.9 | Mandibular Third Molars | Sites: 20 Protocol: PRF Sites: 20 Protocol: PRF | PRP: 1200 rpm x 10 min with citrate phosphate dextrose adenine + 2000rpm x 10 min with calcium chloride PRF: 3000 rpm x 10 min | Landry’s healing index. Pain VAS. Swelling. Digital panoramic radiographs. | VAS scores at 1, 3 and 7 days: PRF: 1.8 ± 0.7, 2.2 ± 0.7, 0 PRP: 2.3 ± 0.8. 2.7 ± 1, 0.1 ± 0.2 | none | None |
Caymaz & Uyanik [37], Turkey | RCT (II) - High | Sites: 54 Males: 12 Females: 15 Age: (18–26) | Mandibular Third Molars | Sites: 27 Protocol: A-PRF Sites: 27 Protocol: L-PRF | A-PRF: 1500 rpm x 14 min (Elektro-mag M415P, Istanbul, Turkey) L-PRF: 3000 rpm x 10 min (Elektro-mag M415P, Istanbul, Turkey) | Pain VAS, and the number of analgesic tablets taken. Trismus and swelling. | VAS scores at 1, 2, 3 and 7 days: A-PRF: 31.56 ± 5.04, 15.67 ± 3.42, 7.03 ± 1.68, 1.67 ± 0.9 L-PRF: 48.3 ± 5.48, 32.44 ± 4.98, 19.01 ± 3.48, 3.22 ± 1.15 | A-PRF | None |
Unakalkar et al., [37], India | Cohort Study (III) - Low | Sites: 25 Males: NR Females: NR Age: (18–40) | Mandibular Third Molars | Sites: NR Protocol: PRF Sites: NR Protocol: PRP | NR | Pain VAS, trismus, and swelling were Periodontal health. Bone healing based on lamina dura score, density score, and trabecular pattern score. Duration of surgery, volume of local anaesthetic solution, and any intraoperative complications. | VAS scores at 1, 3 and 7 days: PRF: 6.33 ± 1.11, 4.07 ± 1.71, 1.73 ± 1.28 PRP: 5.93 ± 1.28, 3.73 ± 1.44, 1.47 ± 1.5 | none | None |
Dutta et al., [35], India | RCT (II) - Moderate | Sites: 40 Males: 27 Females: 13 Age: 27 ± 5 (17–36) | Mandibular Third Molars | Sites: 10 Protocol: Control Sites: 10 Protocol: HA Sites: 10 rotocol: PRF Sites: 10 Protocol: PRP | PRP:2000rpm x 15 min with citrate phosphate dextrose adenine + 3000 rpm x 10 min with calcium chloride PRF: 3000 rpm x 10 min with Calcium gluconate | Swelling, pain Wong-Baker VAS, dry socket Blum’s criteria, and soft tissue healing. Bone healing intraoral periapical radiographs. | VAS scores at 1 and 3 days: Control: 5.4 ± 1.7, 3.6 ± 1.13 PRF: 2.4 ± 0.75, 0.8 ± 0.25 PRP: 2.9 ± 0.91, 1.3 ± 0.41 HA: 5 ± 1.58, 3.6, 1.13 | none | None |
