Fig. 5: Prognostic value of the RSK1-USP1 axis in AML patients. | Blood Cancer Journal

Fig. 5: Prognostic value of the RSK1-USP1 axis in AML patients.

From: RSK1 dependency in FLT3-ITD acute myeloid leukemia

Fig. 5

A USP1 expression across patient risk stratification following ELN 2017 classification. TCGA: Favorable (Fav; n = 51), Intermediate (Int; n = 42), Adverse (Adv; n = 61). Statistics assessed by two-tailed Student’s t-test. BeatAML: Fav (n = 118), Fav/Int (n = 14), Int (n = 150), Int/Adv (n = 7), Adv (n = 162). Statistics comparing pooled group of Fav and Fav/Int against pooled group of Int, Int/Adv, and Adv assessed by two-tailed Student’s t-test. B Kaplan–Meier survival analysis of combined TCGA LAML and BeatAML cohorts. Patients were stratified into USP1 and RPS6KA1 high and low groups by median gene expression. Statistics were assessed by log-rank test compared to the USP1lowRPS6KA1low group.

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