Table 1 Patient Characteristics.

From: Outcomes in patients with classic Hodgkin lymphoma refractory or intolerant to brentuximab vedotin and anti-PD-1 therapy: a real world analysis from 15 U.S. academic centers

 

All Patients

Refractory (DR)

Intolerant (INT)

 

n = 173

n = 127

n = 46

Age at Diagnosis, median (range)

34 (16–89)

33 (16-89)

40 (18-87)

Sex, n (%)

   

 Male

105 (60.7)

76 (59.8)

29 (63.0)

 Female

68 (39.3)

51 (40.2)

17 (37.0)

Race, n (%)

   

 Caucasian

136 (78.6)

100 (78.7)

36 (78.3)

 African American

25 (14.5)

18 (14.2)

7 (15.2)

 Hispanic

6 (3.5)

5 (3.9)

1 (2.2)

 Other

6 (3.5)

5 (3.2)

2 (4.4)

cHL Subtype

   

 Nodular Sclerosing

118 (68.2)

86 (67.7)

32 (69.6)

 Mixed Cellularity

18 (10.4)

10 (7.9)

8 (17.4)

 Lymphocyte Rich

1 (0.6)

1 (0.8)

0 (0)

 Lymphocyte Deplete

6 (3.5)

6 (4.7)

0 (0)

 Unknown

30 (17.3)

24 (18.9)

6 (13.0)

Stage At Diagnosis

 Limited (I-II)

36 (20.8)

29 (22.8)

7 (15.2)

 Advanced (III-IV)

132 (76.3)

97 (76.4)

35 (76.1)

 Unknown

5 (2.9)

1 (0.8)

4 (8.7)

Front-line Therapy

 ABVD/AVD

134 (77.5)

96 (75.6)

38 (82.6)

 BV-AVD

15 (8.7)

12 (9.5)

3 (6.5)

 BV + Nivo

5 (2.9)

5 (3.9)

0 (0)

 BV +/- Chemo

10 (5.8)

7 (5.5)

3 (6.5)

 Other

9 (5.2)

7 (5.5)

2 (4.4)

Front-line CR

 Yes

63 (36.4)

44 (34.7)

19 (41.3)

 No

105 (60.7)

81 (63.8)

24 (52.2)

 Unknown

5 (2.9)

2 (1.6)

3 (6.5)

Front-line Refractory

   

 Yes

100 (57.8)

77 (60.6)

23 (50.0)

 No

71 (41.0)

49 (38.6)

22 (47.8)

 Unknown

2 (1.2)

1 (0.8)

1 (2.2)

  1. Baseline characteristics of patients with DR/INT classic Hodgkin lymphoma stratified by DR or INT.
  2. DR Double Refractory, INT Intolerant, cHL Classical Hodgkin Lymphoma, ABVD Adriamycin, Bleomycin, Vinblastine, Decarbazine, BV Brentuximab Vedotin, Nivo Nivolumab, CR Complete Response.