Table 2 Significant variables selected for prognostic models for outcome in primary myelodysplastic syndrome in Asia.
From: A clinico-genomic prognostic model for primary myelodysplastic neoplasm in Asia
 | OS | LFS | TTP-sAML | ||||||
---|---|---|---|---|---|---|---|---|---|
Variable | Weight | HR | 95% Bootstrap CIa | Weight | HR | 95% Bootstrap CIa | Weight | HR | 95% Bootstrap CIa |
Age | 0.02444 | 1.02474 | (1.02473 – 1.02482) | 0.01571 | 1.01583 | (1.01572–1.01591) | −0.01541 | 0.98471 | (0.98462–0.98497) |
Sex | |||||||||
 Male | 0.15225 | 1.16445 | (1.16324–1.17618) | 0.10747 | 1.11346 | (1.10668–1.11664) | 0.01917 | 1.01936 | (1.01912–1.01944) |
 Female | 0.00000 | 1.00000 | (1.00000–1.00000) | 0.00000 | 1.00000 | (1.00000–1.00000) | 0.00000 | 1.00000 | (1.00000–1.00000) |
2016 WHO Classification | |||||||||
 MDS-SLD | −0.57814 | 0.56094 | (0.55977–0.57220) | −0.61374 | 0.54132 | (0.52905–0.54787) | −0.91230 | 0.40160 | (0.39947–0.40229) |
 MDS-MLD | −0.31948 | 0.72653 | (0.71934–0.72719) | −0.36554 | 0.69382 | (0.69324–0.69398) | −0.54750 | 0.57840 | (0.57713–0.57876) |
 MDS-RS-SLD | −0.63207 | 0.53149 | (0.52917–0.55557) | −0.72286 | 0.48536 | (0.46888–0.49436) | −1.85464 | 0.15651 | (0.15638–0.15683) |
 MDS−RS−MLD | −0.59948 | 0.54910 | (0.54802–0.56141) | −0.52869 | 0.58938 | (0.57163–0.59880) | −0.17623 | 0.83842 | (0.82315–0.84378) |
 MDS-EB-1 | 0.28575 | 1.33077 | (1.33000–1.33874) | 0.29865 | 1.34804 | (1.33625–1.35464) | 0.48093 | 1.61757 | (1.61314–1.61912) |
 MDS-EB-2 | 0.29217 | 1.33933 | (1.33921–1.34017) | 0.37191 | 1.45050 | (1.44730–1.45660) | 0.76088 | 2.14016 | (2.13995–2.14077) |
 MDS-5q | −1.50265 | 0.22254 | (0.19629–0.22539) | −1.27804 | 0.27858 | (0.26434–0.30490) | −1.76630 | 0.17096 | (0.16717–0.18225) |
 MDS-U | −0.36229 | 0.69608 | (0.68857–0.69687) | −0.37974 | 0.68404 | (0.68397–0.68436) | −1.01619 | 0.36197 | (0.36176–0.36206) |
Hematologic parameters | |||||||||
 WBC Count | 0.01307 | 1.01316 | (1.01297–1.01466) | 0.01456 | 1.01466 | (1.01351–1.01523) | 0.02216 | 1.02241 | (1.02190–1.02258) |
 Platelet Count | −0.00127 | 0.99873 | (0.99839–0.99877) | −0.00098 | 0.99902 | (0.99889–0.99922) | - | - | - |
 Hemoglobin | -0.07685 | 0.92603 | (0.91263–0.92749) | -0.07441 | 0.92829 | (0.92228–0.93877) | - | - | - |
 PB blast percent | - | - | - | 0.01761 | 1.01776 | (1.01450–1.01953) | 0.03834 | 1.03909 | (1.03697–1.03982) |
Karyotypic abnormality | |||||||||
 Monosomy 7 | 0.31198 | 1.36613 | (1.35812–1.43411) | 0.22501 | 1.25234 | (1.22970–1.26190) | - | - | - |
 del(5q) | 0.24467 | 1.27719 | (1.27386–1.29950) | 0.23900 | 1.26998 | (1.23261–1.29024) | 0.50351 | 1.65452 | (1.59546–1.67518) |
 Trisomy 19 | - | - | - | 1.12462 | 3.07906 | (2.59119–3.33614) | - | - | - |
 Isochromosome 17q | - | - | - | - | - | - | 1.99102 | 7.32299 | (6.74685–7.52573) |
Gene mutations | |||||||||
 GNAS | 0.40308 | 1.49643 | (1.47836–1.67354) | 0.44794 | 1.56508 | (1.43576–1.64495) | 0.44179 | 1.55548 | (1.49348–1.57760) |
 PTPN11 | - | - | - | 0.3279 | 1.38805 | (1.26208–1.46727) | - | - | - |
 TP53 | 0.34496 | 1.41193 | (1.40006–1.52533) | 0.28295 | 1.32704 | (1.25683–1.36884) | - | - | - |
 NOTCH1 | -0.08251 | 0.92080 | (0.90408–0.92263) | - | - | - | - | - | - |
 NPM1 | - | - | - | - | - | - | 0.56248 | 1.75501 | (1.69586–1.77579) |
 NRAS | - | - | - | - | - | - | 0.44191 | 1.55568 | (1.51593–1.56954) |
 IDH2 | - | - | - | - | - | - | 0.41349 | 1.51208 | (1.47590–1.52452) |
 SF3B1 | - | - | - | - | - | - | 0.24917 | 1.28296 | (1.25751–1.29179) |
 TET2 | −0.10915 | 0.89660 | (0.89403–0.92453) | −0.08289 | 0.92045 | (0.90960–0.93029) | - | - | - |
 CUX1 | −0.10947 | 0.89630 | (0.87073–0.89924) | - | - | - | - | - | - |
 DNMT3A | −0.11846 | 0.88829 | (0.88170–0.88919) | −0.10695 | 0.89857 | (0.89297–0.90883) | - | - | - |
 ZRSR2 | −0.12356 | 0.88377 | (0.85789–0.88627) | −0.1003 | 0.90457 | (0.89595–0.91922) | - | - | - |
 ASXL1 | −0.12599 | 0.88162 | (0.86789–0.88377) | −0.11591 | 0.89056 | (0.88362–0.90315) | - | - | - |
 EZH2 | - | - | - | −0.15696 | 0.85474 | (0.84266–0.87690) | - | - | - |
 ATRX | −0.16932 | 0.84424 | (0.82349–0.84682) | −0.18045 | 0.83490 | (0.82254–0.85601) | −0.23702 | 0.78898 | (0.78401–0.80370) |
 RUNX1 | −0.19379 | 0.82383 | (0.80136–0.82624) | −0.09422 | 0.91008 | (0.90592–0.91884) | 0.22968 | 1.25820 | (1.22887–1.26835) |
 PTEN | −0.22501 | 0.79851 | (0.74218–0.80422) | −0.22029 | 0.80229 | (0.77525–0.84767) | - | - | - |
 CDKN2A | −0.23042 | 0.79420 | (0.75545–0.79832) | - | - | - | - | - | - |
 IKZF1 | −0.23420 | 0.79120 | (0.76324–0.79414) | −0.33689 | 0.71399 | (0.69156–0.75120) | -0.33725 | 0.71373 | (0.70732–0.73259) |
 CALR | −0.37151 | 0.68969 | (0.59998–0.69920) | −0.52079 | 0.59405 | (0.55002–0.66829) | −0.67605 | 0.50862 | (0.49742–0.54128) |
 MYD88 | −0.44747 | 0.63924 | (0.54838–0.64871) | −0.41401 | 0.66100 | (0.62155–0.72704) | - | - | - |
 WT1 | - | - | - | - | - | - | −0.93729 | 0.39169 | (0.37770–0.43344) |