Table 2 Significant variables selected for prognostic models for outcome in primary myelodysplastic syndrome in Asia.

From: A clinico-genomic prognostic model for primary myelodysplastic neoplasm in Asia

 

OS

LFS

TTP-sAML

Variable

Weight

HR

95% Bootstrap CIa

Weight

HR

95% Bootstrap CIa

Weight

HR

95% Bootstrap CIa

Age

0.02444

1.02474

(1.02473 – 1.02482)

0.01571

1.01583

(1.01572–1.01591)

−0.01541

0.98471

(0.98462–0.98497)

Sex

 Male

0.15225

1.16445

(1.16324–1.17618)

0.10747

1.11346

(1.10668–1.11664)

0.01917

1.01936

(1.01912–1.01944)

 Female

0.00000

1.00000

(1.00000–1.00000)

0.00000

1.00000

(1.00000–1.00000)

0.00000

1.00000

(1.00000–1.00000)

2016 WHO Classification

 MDS-SLD

−0.57814

0.56094

(0.55977–0.57220)

−0.61374

0.54132

(0.52905–0.54787)

−0.91230

0.40160

(0.39947–0.40229)

 MDS-MLD

−0.31948

0.72653

(0.71934–0.72719)

−0.36554

0.69382

(0.69324–0.69398)

−0.54750

0.57840

(0.57713–0.57876)

 MDS-RS-SLD

−0.63207

0.53149

(0.52917–0.55557)

−0.72286

0.48536

(0.46888–0.49436)

−1.85464

0.15651

(0.15638–0.15683)

 MDS−RS−MLD

−0.59948

0.54910

(0.54802–0.56141)

−0.52869

0.58938

(0.57163–0.59880)

−0.17623

0.83842

(0.82315–0.84378)

 MDS-EB-1

0.28575

1.33077

(1.33000–1.33874)

0.29865

1.34804

(1.33625–1.35464)

0.48093

1.61757

(1.61314–1.61912)

 MDS-EB-2

0.29217

1.33933

(1.33921–1.34017)

0.37191

1.45050

(1.44730–1.45660)

0.76088

2.14016

(2.13995–2.14077)

 MDS-5q

−1.50265

0.22254

(0.19629–0.22539)

−1.27804

0.27858

(0.26434–0.30490)

−1.76630

0.17096

(0.16717–0.18225)

 MDS-U

−0.36229

0.69608

(0.68857–0.69687)

−0.37974

0.68404

(0.68397–0.68436)

−1.01619

0.36197

(0.36176–0.36206)

Hematologic parameters

 WBC Count

0.01307

1.01316

(1.01297–1.01466)

0.01456

1.01466

(1.01351–1.01523)

0.02216

1.02241

(1.02190–1.02258)

 Platelet Count

−0.00127

0.99873

(0.99839–0.99877)

−0.00098

0.99902

(0.99889–0.99922)

-

-

-

 Hemoglobin

-0.07685

0.92603

(0.91263–0.92749)

-0.07441

0.92829

(0.92228–0.93877)

-

-

-

 PB blast percent

-

-

-

0.01761

1.01776

(1.01450–1.01953)

0.03834

1.03909

(1.03697–1.03982)

Karyotypic abnormality

 Monosomy 7

0.31198

1.36613

(1.35812–1.43411)

0.22501

1.25234

(1.22970–1.26190)

-

-

-

 del(5q)

0.24467

1.27719

(1.27386–1.29950)

0.23900

1.26998

(1.23261–1.29024)

0.50351

1.65452

(1.59546–1.67518)

 Trisomy 19

-

-

-

1.12462

3.07906

(2.59119–3.33614)

-

-

-

 Isochromosome 17q

-

-

-

-

-

-

1.99102

7.32299

(6.74685–7.52573)

Gene mutations

 GNAS

0.40308

1.49643

(1.47836–1.67354)

0.44794

1.56508

(1.43576–1.64495)

0.44179

1.55548

(1.49348–1.57760)

 PTPN11

-

-

-

0.3279

1.38805

(1.26208–1.46727)

-

-

-

 TP53

0.34496

1.41193

(1.40006–1.52533)

0.28295

1.32704

(1.25683–1.36884)

-

-

-

 NOTCH1

-0.08251

0.92080

(0.90408–0.92263)

-

-

-

-

-

-

 NPM1

-

-

-

-

-

-

0.56248

1.75501

(1.69586–1.77579)

 NRAS

-

-

-

-

-

-

0.44191

1.55568

(1.51593–1.56954)

 IDH2

-

-

-

-

-

-

0.41349

1.51208

(1.47590–1.52452)

 SF3B1

-

-

-

-

-

-

0.24917

1.28296

(1.25751–1.29179)

 TET2

−0.10915

0.89660

(0.89403–0.92453)

−0.08289

0.92045

(0.90960–0.93029)

-

-

-

 CUX1

−0.10947

0.89630

(0.87073–0.89924)

-

-

-

-

-

-

 DNMT3A

−0.11846

0.88829

(0.88170–0.88919)

−0.10695

0.89857

(0.89297–0.90883)

-

-

-

 ZRSR2

−0.12356

0.88377

(0.85789–0.88627)

−0.1003

0.90457

(0.89595–0.91922)

-

-

-

 ASXL1

−0.12599

0.88162

(0.86789–0.88377)

−0.11591

0.89056

(0.88362–0.90315)

-

-

-

 EZH2

-

-

-

−0.15696

0.85474

(0.84266–0.87690)

-

-

-

 ATRX

−0.16932

0.84424

(0.82349–0.84682)

−0.18045

0.83490

(0.82254–0.85601)

−0.23702

0.78898

(0.78401–0.80370)

 RUNX1

−0.19379

0.82383

(0.80136–0.82624)

−0.09422

0.91008

(0.90592–0.91884)

0.22968

1.25820

(1.22887–1.26835)

 PTEN

−0.22501

0.79851

(0.74218–0.80422)

−0.22029

0.80229

(0.77525–0.84767)

-

-

-

 CDKN2A

−0.23042

0.79420

(0.75545–0.79832)

-

-

-

-

-

-

 IKZF1

−0.23420

0.79120

(0.76324–0.79414)

−0.33689

0.71399

(0.69156–0.75120)

-0.33725

0.71373

(0.70732–0.73259)

 CALR

−0.37151

0.68969

(0.59998–0.69920)

−0.52079

0.59405

(0.55002–0.66829)

−0.67605

0.50862

(0.49742–0.54128)

 MYD88

−0.44747

0.63924

(0.54838–0.64871)

−0.41401

0.66100

(0.62155–0.72704)

-

-

-

 WT1

-

-

-

-

-

-

−0.93729

0.39169

(0.37770–0.43344)

  1. OS overall survival, LFS leukemia-free survival, TTP-sAML time-to-progression to secondary acute myeloid leukemia, H.R. hazard ratio for event, WHO World Health Organization, MDS-SLD myelodysplastic syndrome with single lineage dysplasia, MDS-MLD myelodysplastic syndrome with multilineage dysplasia, MDS-RS-SLD myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia, MDS-RS-SLD myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia, MDS-EB-1 myelodysplastic syndrome with excess blasts-1, MDS-EB-2 myelodysplastic syndrome with excess blasts-2, MDS-5q myelodysplastic syndrome with isolated 5q deletion, MDS-U myelodysplastic syndrome-unclassifiable, WBC white blood cell, PB peripheral blood.
  2. aThe 95% bootstrap CI for the hazard ratio is estimated by 1000 bootstrap samples.