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Chronic graft-versus-host disease features in double unit cord blood transplantation according to National Institutes of Health 2005 cGVHD Consensus criteria

Bone Marrow Transplantation volume 53, pages 417–421 (2018)Cite this article

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Chronic graft-versus-host disease (cGVHD) is a multi-organ disorder and the main cause of transplant related death. Usually, onset of cGVHD occurs within the first 3 years post-transplantation [1] and may linger for several years with devastating effects on patients’ quality of life.

The original Seattle criteria [2] (Table 1) has been the most frequently used classification of cGVHD despite limitations in describing the extent of the disease, involved organs, and functional impact [1]. A major revision of the cGVHD criteria was published in 2005 by the National Institutes of Health (NIH) Consensus Conference in Clinical Trials in cGVHD (NCC 2005) to standardize cGVHD staging for better diagnosis and to propose a scoring system that includes overall severity as well as organ–oriented information (Table 1) [1, 3].

Table 1 Criteria for chronic GVHD diagnosis and staging
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Acknowledgements

We thank all the participating centers mentioned below: Belgium: Universitair Ziekenhuis Brussel, Brussels; Brazil: Hospital Sirio-Libanes Hematology Bone Marrow Transplant Unit, Sao Paulo; Denmark: Rigshospitalet, Copenhagen; Finland: Helsinki University Central Hospital, Helsinki; Turku University Central Hospital, Turku; France: Angers—CHR Angers; Haut-Lévêque, Bordeaux; Augustin Morvan, Brest; Henri Mondor, Créteil; Tronche CHU/Albert Michallon, Grenoble; Claude Huriez, Lille; Edouard Herriot, Lyon; La Timone, Marseille; Archet, Nice; Hôpital St. Louis Service Hemato-oncologie, Paris; Saint-Louis, Paris; Pontchaillou, Rennes; Centre Henry Becquerel, Rouen; Hopital Nord/Institut de Cancérologie de la Loire, Saint-Etienne; Hautepierre, Strasbourg; IGR, Villejuif; Klinikum Augsburg, Augsburg; Germany: Düsseldorf Universitaetsklinikum; University Hospital Eppendorf, Hamburg; Klinikum Grosshadern, Munich; Klinkum Rechts der Isar, Munich; Greece: Evangelismos Hospital, Athens; Israel: Chaim Sheba Medical Center, Tel-Hashomer; Italy: Azienda Ospedaliero Universitaria Meyer—Ospedale di Careggi, Firenze; University La Sapienza, Roma; New Zealand: Christchurch—Canterbury Health Laboratories; Norway: Rikshospitalet Department of Medicine; Saudi Arabia: King Faisal Specialist Hospital & Research Centre, Riyadh; Sweden: Sahlgrenska University Hospital, Goeteborg; Karolinska University Hospital Children’s Hospital, Stockholm; University Hospital, Uppsala; Switzerland: Hopitaux Universitaires de Geneve, Geneva; The Netherlands: University Hospital, Leiden; Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam; University Medical Centre, Utrecht; United Kingdom: Birmingham Heartlands Hospital, Birmingham; Queen Elizabeth Hospital, Birmingham; Manchester Royal Infirmary Haematology, Manchester; Nottingham City Hospital, Nottingham.

Author contributions

H.H., A.R., V.R., and E.G. designed the study, E.X. collected the data, H.H. and F.V. analyzed the data, H.H., F.V., and H.R. wrote the paper. J.C., H.S., G.S., M.Mi, D.K., E.P., J.Y.C., H.V., M.Me, P.S.R., and R.D. provided cases for the study. All authors edited and approved the manuscript.

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Authors and Affiliations

  1. Eurocord, Hôpital Saint Louis, APHP, IUH, Paris, France

    Hiromi Hayashi, Annalisa Ruggeri, Fernanda Volt, Hanadi Rafii, Chantal Kenzey, Erick Xavier, Vanderson Rocha & Eliane Gluckman

  2. Monacord, Centre scientifique de Monaco, Monaco-Ville, Monaco

    Hiromi Hayashi, Fernanda Volt, Hanadi Rafii, Chantal Kenzey & Eliane Gluckman

  3. Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France

    Annalisa Ruggeri

  4. Department of Hematology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands

    Jan J. Cornelissen

  5. Hôpital Saint-Louis, APHP, University Paris-Diderot, Paris, France

    Gerard Socié

  6. Rigshospitalet, Copenhagen, Denmark

    Henrik Sengeloev

  7. Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre Benite, France

    Mauricette Michallet

  8. Evangelismos Hospital, Athens, Greece

    Dimitrios Karakasis

  9. University Medical Centre, Utrecht, Netherlands

    Eefke Petersen

  10. Centre Hospitalier Universitaire Albert Michallon, Grenoble, France

    Jean Yves Cahn

  11. Leiden University Hospital, Leiden, Netherlands

    Hendrik Veelken

  12. Centre Hospitalier Regional Universitaire, Angers, France

    Mélanie Mercier

  13. Hopital de l’Archet, Nice, France

    Pierre-Simon Rohrlich

  14. Sirio Libanes Hospital and University of Sao Paulo, Sao Paulo, Brazil

    Erick Xavier & Vanderson Rocha

  15. Hospital Universitario Puerta de Hierro, Madrid, Spain

    Rafael F. Duarte

  16. Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland

    Grzegorz W. Basak

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  1. Hiromi Hayashi
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  2. Annalisa Ruggeri
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  20. Eliane Gluckman
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on behalf of Eurocord and the Complications and Quality of Life WP of EBMT

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Correspondence to Hiromi Hayashi.

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The authors declare that they have no conflict of interest.

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Hayashi, H., Ruggeri, A., Volt, F. et al. Chronic graft-versus-host disease features in double unit cord blood transplantation according to National Institutes of Health 2005 cGVHD Consensus criteria. Bone Marrow Transplant 53, 417–421 (2018). https://doi.org/10.1038/s41409-017-0061-9

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