Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

The impact of blood donation on bone marrow harvest efficiency

Bone Marrow Transplantation volume 57, pages 507–509 (2022)Cite this article

Subjects

Access through your institution
Buy or subscribe

Bone marrow (BM) donation is a procedure that takes place in an operating room. In many hospitals, autologous blood is collected from donor before the harvest and reinfused at the time of the donation, similar like in the case of other planned surgical operations. Blood donation causes reduced preoperative hemoglobin concentration, but autotransfusion after BM collection compensates this effect [1, 2].

The intention of autotransfusion is to increase patient safety, but this procedure has its disadvantages. The donors are exposed to the risk of infections, allergic reactions, or misidentification of blood unit due to human errors. Sometimes operation is canceled or postponed, and autologous unit must be disposed of. Moreover, hospitals bear the costs of collection, storage and transfusion of red cell concentrates [3,4,5]. On the other hand, the blood loss stimulates hematopoiesis, so it is possible that preparing for autotransfusion has an impact on the quality of collected BM.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lown RN, Philippe J, Navarro W, van Walraven SM, Philips-Johnson L, Fechter M, et al. Unrelated adult stem cell donor medical suitability: recommendations from the World Marrow Donor Association Clinical Working Group Committee. Bone Marrow Transplant. 2014;49:880–6.

    Article  CAS  Google Scholar 

  2. Spitzer TR, Sugrue MW, Gonzalez C, O’Donnell P, Confer D, Fuchs E, et al. Transfusion practices for bone marrow harvests: a survey analysis from the AABB Bone Marrow Quality Improvement Initiative Working Group. Bone Marrow Transplant. 2017;52:1199–1200.

    Article  CAS  Google Scholar 

  3. Fujiwara SI, Ikeda K, Kino S, Tanaka A, Hasegawa Y, Fujino K, et al. Clinical significance of autologous blood transfusions in bone marrow harvest from unrelated donors. Int J Hematol. 2020;111:833–9.

    Article  CAS  Google Scholar 

  4. Farhadfar N, Murthy HS, Logan BR, Sees JA, Ayas M, Battiwalla M, et al. Impact of autologous blood transfusion after bone marrow harvest on unrelated donor’s health and outcome: a CIBMTR analysis. Bone Marrow Transplant. 2020;55:2121–31.

    Article  CAS  Google Scholar 

  5. Kim-Wanner SZ, Luxembourg B, Schmidt AH, Schäfer R, Möller N, Herbert E, et al. Introduction of principles of blood management to healthy donor bone marrow harvesting. Vox Sang. 2020;115:802–12.

    Article  Google Scholar 

  6. Sutherland DR, Anderson L, Keeney M, Nayar R, Chin-Yee I. The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering. J Hematother. 1996;5:213–26.

    Article  CAS  Google Scholar 

  7. Mijovic A, Britten C, Regan F, Harrison J. Preoperative autologous blood donation for bone marrow harvests: are we wasting donors’ time and blood? Transfus Med. 2006;16:57–62.

    Article  CAS  Google Scholar 

  8. Manuel SP, Spitzer TR, Ishizawa Y. Preoperative autologous blood donation in healthy bone marrow donors contributes to pre-procedure anemia. Bone Marrow Transplant. 2017;52:1191–3.

    Article  CAS  Google Scholar 

  9. Gilli IO, Vigorito AC, Benites BD. Revisiting old practices: more restricted indication of preoperative autologous blood donation in healthy bone marrow donors according to baseline hemoglobin levels. Transfus Apher Sci. 2019;58:323–5.

    Article  Google Scholar 

  10. Arora K, Kelley J, Martinez F, Tholpady A. Preoperative autologous blood collection before bone marrow harvests in haploidentical related donors: is it justified? Transfusion. 2018;58:1618–25.

    Article  Google Scholar 

  11. Lysák D, Hejretová L, Hrabetová M, Jindra P. Should we stop collecting the preoperative autologous blood before bone marrow harvest? J Clin Med. 2021;10:2134.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Street: Wybrzeze Armii Krajowej 15, 44-102, Gliwice, Poland

    Iwona Mitrus, Marcin Wilkiewicz, Wojciech Fidyk, Agnieszka Ciomber, Andrzej Smagur, Magdalena Glowala-Kosinska, Agata Chwieduk, Paulina Borzdzilowska, Malgorzata Sobczyk-Kruszelnicka, Wlodzimierz Mendrek, Jacek Najda, Tomasz Czerw & Sebastian Giebel

Authors
  1. Iwona Mitrus
    View author publications

    Search author on:PubMed Google Scholar

  2. Marcin Wilkiewicz
    View author publications

    Search author on:PubMed Google Scholar

  3. Wojciech Fidyk
    View author publications

    Search author on:PubMed Google Scholar

  4. Agnieszka Ciomber
    View author publications

    Search author on:PubMed Google Scholar

  5. Andrzej Smagur
    View author publications

    Search author on:PubMed Google Scholar

  6. Magdalena Glowala-Kosinska
    View author publications

    Search author on:PubMed Google Scholar

  7. Agata Chwieduk
    View author publications

    Search author on:PubMed Google Scholar

  8. Paulina Borzdzilowska
    View author publications

    Search author on:PubMed Google Scholar

  9. Malgorzata Sobczyk-Kruszelnicka
    View author publications

    Search author on:PubMed Google Scholar

  10. Wlodzimierz Mendrek
    View author publications

    Search author on:PubMed Google Scholar

  11. Jacek Najda
    View author publications

    Search author on:PubMed Google Scholar

  12. Tomasz Czerw
    View author publications

    Search author on:PubMed Google Scholar

  13. Sebastian Giebel
    View author publications

    Search author on:PubMed Google Scholar

Contributions

IM wrote the manuscript. MSK, WM, JN, TC, SG performed bone marrow collections and provided patient data. MW, WF, ACiomber, AS, MGK, AChwieduk, and PB performed laboratory analyses and collected the data. SG reviewed the manuscript. All authors read the manuscript and approved the final version.

Corresponding author

Correspondence to Iwona Mitrus.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mitrus, I., Wilkiewicz, M., Fidyk, W. et al. The impact of blood donation on bone marrow harvest efficiency. Bone Marrow Transplant 57, 507–509 (2022). https://doi.org/10.1038/s41409-022-01573-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41409-022-01573-1

Search

Advanced search

Quick links