Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

The clinical benefit of acute GVHD depends on the age at transplantation in patients with adult T-cell leukemia–lymphoma on behalf of the ATL Working Group of the Japan Society for Transplantation and Cellular Therapy

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The impact of age at allo-HCT on overall survival according to the maximum grade of aGVHD.

Data availability

The participants of this study did not give written consent for their data to be shared publicly, so due to the sensitive nature of the research supporting data is not available.

References

  1. Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, et al. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. J Clin Oncol. 2019;37:677–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. O’Neill AT, Chakraverty R. Graft Versus Leukemia: Current Status and Future Perspectives. J Clin Oncol. 2021;39:361–72.

    Article  PubMed  Google Scholar 

  3. Kanda J, Hishizawa M, Utsunomiya A, Taniguchi S, Eto T, Moriuchi Y, et al. Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study. Blood. 2012;119:2141–8.

    Article  CAS  PubMed  Google Scholar 

  4. Lin RJ, Artz AS. Allogeneic hematopoietic cell transplantation for older patients. Hematology Am Soc Hematol Educ Program. 2021;2021:254–63.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Fuji S, Hakoda A, Kanda J, Murata M, Terakura S, Inamoto Y, et al. Impact of HLA disparity on the risk of overall mortality in patients with grade II-IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation. Bone Marrow Transplant. 2021;56:2990–6.

    Article  CAS  PubMed  Google Scholar 

  6. Holtan SG, MacMillan ML. A risk-adapted approach to acute GVHD treatment: are we there yet? Bone Marrow Transplant. 2016;51:172–5.

    Article  CAS  PubMed  Google Scholar 

  7. Schoemans HM, Lee SJ, Ferrara JL, Wolff D, Levine JE, Schultz KR, et al. EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment. Bone Marrow Transplant. 2018;53:1401–15.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Harris AC, Young R, Devine S, Hogan WJ, Ayuk F, Bunworasate U, et al. International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium. Biol Blood Marrow Transplant. 2016;22:4–10.

    Article  PubMed  Google Scholar 

  9. Levine JE, Hogan WJ, Harris AC, Litzow MR, Efebera YA, Devine SM, et al. Improved accuracy of acute graft-versus-host disease staging among multiple centers. Best Pract Res Clin Haematol. 2014;27:283–7.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Weisdorf DJ, Hurd D, Carter S, Howe C, Jensen LA, Wagner J, et al. Prospective grading of graft-versus-host disease after unrelated donor marrow transplantation: a grading algorithm versus blinded expert panel review. Biol Blood Marrow Transplant. 2003;9:512–8.

    Article  PubMed  Google Scholar 

  11. Fuji S, Kurosawa S, Inamoto Y, Nakano N, Miyazaki Y, Miyashita K, et al. Does an increased probability of graft-vs-host disease improve the survival of patients with adult T-cell leukemia-lymphoma? A simulation analysis using a Markov model. Advances in Cell and Gene Therapy 2019;2:e56.

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank the medical, nursing, data processing, laboratory, and clinical staff members at the participating centers for their important contributions to this study and their dedicated patent care. This work was supported by a grant from the Practical Research for Innovative Cancer Control program of the Japan Agency for Medical Research and Development (22ck0106616h0003).

Author information

Authors and Affiliations

Authors

Contributions

SF, YI, JM, and MY designed the study, performed the analyses, and wrote the manuscript. NN, AI, TK, TE, SY, HI, YS, YM, NU, SM, OM, KI, TF, and YA were involved in the acquisition of the analyzed data. All the authors reviewed the manuscript.

Corresponding author

Correspondence to Shigeo Fuji.

Ethics declarations

Competing interests

SF received honoraria from Takeda Pharmaceutical, Chugai Pharmaceutical, CSL Behring, Novartis Pharma, Otsuka Pharmaceutical, Sanofi, and Kyowa Kirin. YA received honoraria from Meiji Seika Pharma, JCR Pharmaceuticals, Novartis Pharma, Kyowa Kirin, AbbVie GK, and Astellas Pharma. MY received honoraria from Takeda Pharmaceutical, Chugai Pharmaceutical, CSL Behring, Novartis Pharma, Otsuka Pharmaceutical, Sanofi, and Daiichi-Sankyo.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fuji, S., Inoue, Y., Makiyama, J. et al. The clinical benefit of acute GVHD depends on the age at transplantation in patients with adult T-cell leukemia–lymphoma on behalf of the ATL Working Group of the Japan Society for Transplantation and Cellular Therapy. Bone Marrow Transplant 58, 729–731 (2023). https://doi.org/10.1038/s41409-023-01969-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41409-023-01969-7

Search

Quick links