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Oral malignant and potentially malignant lesions after allogenic hematopoietic cell transplantation: a 10-year follow-up study

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References

  1. Gratwohl A, Baldomero H, Aljurf M, Pasquini MC, Bouzas LF, Yoshimi A, et al. Hematopoietic stem cell transplantation: a global perspective. JAMA. 2010;303:1617–24. https://doi.org/10.1001/jama.2010.491.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Haverman TM, Raber-Durlacher JE, Rademacher WM, Vokurka S, Epstein JB, Huisman C, et al. Oral complications in hematopoietic stem cell recipients: the role of inflammation. Mediators Inflamm. 2014;2014:378281. https://doi.org/10.1155/2014/378281.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Epstein JB, Raber-Durlacher JE, Wilkins A, Chavarria MG, Myint H. Advances in hematologic stem cell transplant: an update for oral health care providers. Oral Surg Oral Med Oral Pathol Oral Radio Endod. 2009;107:301–12. https://doi.org/10.1016/j.tripleo.2008.12.006.

    Article  Google Scholar 

  4. Asano-Mori Y, Yuasa M, Kageyama K, Kaji D, Nishida A, Takagi S, et al. Secondary Solid Cancers after Allogeneic Hematopoietic Stem Cell Transplantation: A Single Center Experience of 1374 Patients Including 812 Cord Blood Transplant Recipients. Blood. 2017;130:4518. https://doi.org/10.1182/blood.V130.Suppl_1.4518.4518.

    Article  Google Scholar 

  5. Mawardi H, Elad S, Correa ME, Stevenson K, Woo SB, Almazrooa S, et al. Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. Bone Marrow Transpl. 2011;46:884–91. https://doi.org/10.1038/bmt.2011.77.

    Article  CAS  Google Scholar 

  6. Majhail NS, Brazauskas R, Rizzo JD, Sobecks RM, Wang Z, Horowitz MM, et al. Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning. Blood. 2011;117:316–22. https://doi.org/10.1182/blood-2010-07-294629.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Rizzo JD, Curtis RE, Socie G, Sobocinski KA, Gilbert E, Landgren O, et al. Solid cancers after allogeneic hematopoietic cell transplantation. Blood. 2009;113:1175–83. https://doi.org/10.1182/blood-2008-05-158782.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Curtis RE, Metayer C, Rizzo JD, Socie G, Sobocinski KA, Flowers ME, et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood. 2005;105:3802–11. https://doi.org/10.1182/blood-2004-09-3411.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Douglas CM, Jethwa AR, Hasan W, Liu A, Gilbert R, Goldstein D, et al. Long-term survival of head and neck squamous cell carcinoma after bone marrow transplant. Head Neck. 2020;42:3389–95. https://doi.org/10.1002/hed.26402.

    Article  PubMed  Google Scholar 

  10. Tanaka Y, Kurosawa S, Tajima K, Tanaka T, Ito R, Inoue Y, et al. Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transpl. 2017;52:789–91. https://doi.org/10.1038/bmt.2017.4.

    Article  CAS  Google Scholar 

  11. Pfister DG, Spencer S, Adelstein D, Adkins D, Anzai Y, Brizel DM, et al. Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020;18:873–98. https://doi.org/10.6004/jnccn.2020.0031.

    Article  PubMed  Google Scholar 

  12. Santarone S, Natale A, Angelini S, Papalinetti G, Vaddinelli D, Di Bartolomeo A, et al. Secondary oral cancer following hematopoietic cell transplantation. Bone Marrow Transpl. 2021;56:1038–46. https://doi.org/10.1038/s41409-020-01147-z.

    Article  CAS  Google Scholar 

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Mawardi H: Study design, data collection, manuscript write up. Elad S: Study design, manuscript write up. Zadik Y: Study design, manuscript write up. Correa ME: Study design, manuscript write up. Felemban O: Statistical analysis, manuscript write up. Treister NS: Study design, manuscript write up.

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Correspondence to H. Mawardi.

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Mawardi, H., Elad, S., Zadik, Y. et al. Oral malignant and potentially malignant lesions after allogenic hematopoietic cell transplantation: a 10-year follow-up study. Bone Marrow Transplant 60, 89–93 (2025). https://doi.org/10.1038/s41409-024-02443-8

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