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High level serum IL-6 predicts occurrence of TA-TMA

Bone Marrow Transplantation volume 60, pages 400–402 (2025)Cite this article

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Transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe and potentially fatal complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Particularly high mortality rates even over 80% were observed [1]. Extensive endothelial damage leads to terminal complement activation, resulting in microangiopathic hemolytic anemia, consumptive thrombocytopenia and microvascular thrombosis, causing target organ dysfunction [2].

Cytokines play a key role during complement activation and endothelial activation. Notably, interleukin-6 (IL-6), a pro-inflammatory cytokine, may activate the endothelium. Interleukin-10 (IL-10) is an essential anti-inflammatory factor that reduces tissue damage. However, their roles in TA-TMA have not been studied.

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Acknowledgements

The authors would like to thank the We would like to sincerely thank Bone Marrow Transplantation Center nursing team.

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Author notes

  1. These authors contributed equally: Renzhi Zheng, Lin Li, Jianzhi Zhao.

Authors and Affiliations

  1. Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Renzhi Zheng, Lin Li, Diange Jin, Jimin Shi, Yanmin Zhao, Jian Yu, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Congxiao Zhang, He Huang, Yi Luo & Yishan Ye

  2. Department of Hematology, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, China

    Renzhi Zheng & Jianzhi Zhao

  3. Zhijiang College, Zhejiang University of Technology, Shaoxing, China

    Jia Shen

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  1. Renzhi Zheng
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Contributions

All authors contributed to the study conception and design. RZ performed the data collection, statistical analysis, and wrote the original draft; LL and JZ contributed to conceptualization, manuscript writing and editing; DJ, JS, YZ, YJ, XL, LL, HF, and CZ contributed to patient management, data analysis, and provided comments on previous manuscript versions. HH, YL and YY led the conceptualization, supervision, and project administration. All authors read and approved the final manuscript. HH, YL, and YY contributed equally to this work.

Corresponding authors

Correspondence to He Huang, Yi Luo or Yishan Ye.

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The authors declare no competing interests.

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All the patients gave their written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the ethics review committee of the First Affiliated Hospital of Zhejiang University School of Medicine.

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Zheng, R., Li, L., Zhao, J. et al. High level serum IL-6 predicts occurrence of TA-TMA. Bone Marrow Transplant 60, 400–402 (2025). https://doi.org/10.1038/s41409-024-02478-x

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