Table 2 Factors associated with NRM.
Univariate | Multivariate | |||
|---|---|---|---|---|
Characteristics | HR (95% CI) | P value | Adjusted HR (95% CI) | P value |
eGFR | ||||
≥120 | 1 | 1 | ||
90–119 | 1.58 (0.85, 2.95) | 0.15 | 1.45 (0.72, 2.91) | 0.30 |
70-89 | 1.71 (0.89, 3.3) | 0.11 | 1.59 (0.77, 3.26) | 0.21 |
<70 | 3.41 (1.79, 6.51) | 0.0002 | 2.72 (1.3, 5.67) | 0.008 |
<70 vs 70–89 | 1.99 (1.33, 2.98) | 0.0008 | 1.71 (1.14, 2.59) | 0.01 |
<70 vs 90–119 | 2.16 (1.52, 3.05) | <0.0001 | 1.88 (1.30, 2.71) | 0.0008 |
70–89 vs 90–119 | 1.08 (0.75, 1.55) | 0.68 | 1.10 (0.76, 1.59) | 0.62 |
Age category | ||||
18–59 | 1 | 1 | ||
60–69 | 1.23 (0.91, 1.68) | 0.18 | 1.00 (0.67, 1.52) | 0.98 |
70–79 | 1.88 (1.21, 2.9) | 0.005 | 1.46 (0.85, 2.53) | 0.17 |
Sex, Male | 1.01 (0.76, 1.35) | 0.92 | ||
Race | ||||
Black | 1 | |||
Caucasian | 1.33 (0.62, 2.85) | 0.46 | ||
Other | 1.56 (0.57, 4.24) | 0.38 | ||
KPS ≥ 90 vs <90 | 0.54 (0.4, 0.73) | <0.0001 | 1.64 (1.21, 2.23) | 0.001 |
Intensity of conditioning, RIC vs MAC | 1.48 (1.10, 2.00) | 0.01 | 0.87 (0.53, 1.42) | 0.57 |
Graft type, PSC vs BM | 2.20 (1.57, 3.09) | <0.0001 | 2.28 (1.47, 3.52) | 0.0002 |
Donor source | ||||
Haplo | 1 | 1 | ||
RD | 1.55 (0.94, 2.55) | 0.08 | 2.18 (1.24, 3.83) | 0.007 |
URD | 1.83 (1.16, 2.87) | 0.009 | 2.43 (1.42, 4.15) | 0.001 |
Bu/Flu use | 1.46 (1.1, 1.94) | 0.009 | 0.65 (0.41, 1.04) | 0.07 |
PTCy use | 0.77 (0.55, 1.07) | 0.11 | ||
HCT-CI (without renal) | ||||
Low | 1 | 1 | ||
Intermediate | 1.25 (0.77, 2.02) | 0.363 | 1.18 (0.72, 1.92) | 0.51 |
High | 1.65 (1.06, 2.56) | 0.026 | 1.43 (0.91, 2.24) | 0.12 |
CMV donor–receipt | ||||
+/+ | 1 | |||
+/− | 0.91 (0.53, 1.57) | 0.74 | ||
−/+ | 0.97 (0.68, 1.37) | 0.85 | ||
−/− | 0.95 (0.63, 1.42) | 0.79 | ||
DRI | ||||
High | 1 | |||
Intermediate | 1.05 (0.74, 1.5) | 0.79 | ||
Low | 1.11 (0.71, 1.73) | 0.66 | ||
NA | 1.03 (0.43, 2.5) | 0.94 | ||
