Table 3 Multivariate analysis of transplant outcomes.

Number of induction cycles

1

2

0.87 (0.66–1.15)

0.33

0.82 (0.51–1.32)

0.41

1.01 (0.78–1.3)

0.93

1.15 (0.79–1.65)

0.46

1.45 (1.11–1.91)

0.007

1.22 (0.86–1.73

0.27

≥3

1.27 (0.87–1.86)

0.22

1.05 (0.54–2.03)

0.88

1.23 (0.83–1.84)

0.29

1.27 (0.73–2.21)

0.39

1.64 (1.06–2.52)

0.025

1.72 (0.97–3.02)

0.06

Patient age (per 10 years)

1.03 (0.96–1.11)

0.36

0.94 (0.84–1.07)

0.35

1.11 (1.04–1.19)

0.002

1.09 (0.99–1.2)

0.07

1.07 (0.98–1.16)

0.12

1.31 (1.18–1.46)

<0.001

Karnofsky performance status score

≥90

<90

0.87 (0.73–1.05)

0.15

0.99 (0.73–1.34)

0.93

1.11 (0.94–1.32)

0.21

1.12 (0.87–1.42)

0.38

1.03 (0.84–1.27)

0.75

1.17 (0.91–1.52)

0.21

Female donor to male recipient

Yes

1.02 (0.83–1.24)

0.88

1.17 (0.83–1.64)

0.37

1.35 (1.12–1.63)

0.001

1.29 (0.99–1.7)

0.06

0.98 (0.77–1.25)

0.88

0.88 (0.64–1.21)

0.43

Type of ALL

T

Ph+

0.97 (0.78–1.21)

0.77

0.96 (0.67–1.38)

0.83

1.06 (0.86–1.32)

0.57

1.08 (0.79–1.47)

0.63

0.96 (0.73–1.26)

0.78

1.05 (0.76–1.47)

0.76

Ph -

0.99 (0.78–1.24)

0.9

0.73 (0.49–1.09)

0.12

0.98 (0.78–1.23)

0.83

1.03 (0.75–1.43)

0.85

1.04 (0.78–1.37)

0.8

0.97 (0.68–1.39)

0.88

Ph NA

0.8 (0.58–1.09)

0.16

0.66 (0.38–1.15)

0.14

0.97 (0.72–1.3)

0.83

0.86 (0.55–1.36)

0.52

0.94 (0.65–1.37)

0.74

1.11 (0.71–1.72)

0.65

Type of conditioning

RIC

MAC-TBI

1.53 (1.18–1.99)

0.001

1.2 (0.77–1.86)

0.41

1.31 (1.03–1.67)

0.026

1.17 (0.83–1.65)

0.36

0.48 (0.37–0.63)

<0.001

1.62 (1.13–2.34)

0.009

MAC-chemo

1.08 (0.77–1.5)

0.67

0.89 (0.51–1.54)

0.66

1.27 (0.94–1.72)

0.12

1.14 (0.74–1.76)

0.55

0.75 (0.54–1.04)

0.08

1.73 (1.11–2.69)

0.015

Stem cell source

Bone marrow

Peripheral blood

1.01 (0.82–1.24)

0.95

1.01 (0.72–1.42)

0.95

1.36 (1.11–1.66)

0.003

1.65 (1.21–2.25)

0.002

0.86 (0.68–1.09)

0.21

1.23 (0.91–1.67)

0.17

Year of transplant (per 5 years)

0.9 (0.83–0.97)

0.008

0.87 (0.76–0.99)

0.04

0.78 (0.72–0.85)

<0.001

0.87 (0.78–0.98)

0.02

0.84 (0.76–0.92)

<0.001

0.69 (0.61–0.78)

<0.001

Number of induction cycles

1

2

1.35 (1.09–1.68)

0.007

1.34 (1.06–1.7)

0.016

1.18 (0.98–1.43)

0.07

≥3

1.67 (1.18–2.35)

0.004

1.86 (1.28–2.68)

0.001

1.31 (0.98–1.76)

0.06

Patient age (per 10 years)

1.16 (1.08–1.24)

<0.001

1.24 (1.15–1.33)

<0.001

1.08 (1.02–1.14)

0.008

Karnofsky performance status score

≥90

<90

1.1 (0.93–1.29)

0.27

1.18 (0.98–1.41)

0.07

1.09 (0.96–1.25)

0.19

Female donor to male recipient

Yes

0.94 (0.77–1.14)

0.53

0.92 (0.74–1.15)

0.47

1.07 (0.92–1.26)

0.37

Type of ALL

T

Ph+

0.99 (0.8–1.22)

0.93

0.76 (0.6–0.96)

0.019

0.96 (0.8–1.14)

0.6

Ph -

1.01 (0.81–1.26)

0.91

0.95 (0.75–1.21)

0.69

0.93 (0.78–1.12)

0.44

Ph NA

1.01 (0.76–1.35)

0.93

1.06 (0.78–1.44)

0.7

0.87 (0.68–1.11)

0.25

Type of conditioning

RIC

MAC-TBI

0.77 (0.62–0.95)

0.015

0.91 (0.72–1.16)

0.4

0.87 (0.72–1.04)

0.12

MAC-chemo

1.02 (0.79–1.33)

0.88

1.25 (0.93–1.68)

0.13

0.95 (0.76–1.19)

0.65

Stem cell source

Bone marrow

Peripheral blood

0.99 (0.82–1.2)

0.93

1.07 (0.86–1.32)

0.56

1.12 (0.96–1.32)

0.154

Year of transplant (per 5 years)

0.77 (0.72–0.84)

<0.001

0.72 (0.66–0.79)

<0.001

0.87 (0.82–0.93)

<0.001