Fig. 2: Cerebrospinal-fluid (CSF) cytokine profile at peak grade 2–4 ICANS.
From: ICANS risk model in CD19 CAR-T therapy: insights from serum and CSF cytokine profiling
Heat-map of CSF concentrations of IL-6, IL-15, GM-CSF and IL-1β (pg/mL) measured at the time of maximum neurotoxicity (grade 2–4; n = 8). Each row represents an individual patient; columns correspond to cytokine levels. Color intensity reflects the measured concentration (scale bar); numeric values are overlaid in each cell. A side bar encodes the ICANS grade (2, 3 or 4) for each patient. CSF cerebrospinal fluid, GM-CSF granulocyte–macrophage colony-stimulating factor, IL interleukin, ICANS immune effector cell-associated neurotoxicity syndrome.
