Table 1 Definition of advanced-stage CTCL and high-risk advanced-stage CTCL.

From: Allogeneic hematopoietic cell transplant in cutaneous T-cell lymphomas: recommendations from the EBMT PH&G Committee

Disease category

Definition

Advanced-stage CTCL

• Mycosis fungoides (MF) stage IIB to IVB (according to ISCL/EORTC staging)

• Sézary Syndrome

High-risk advanced-stage CTCL

Presence of one or more poor prognostic features:

• Large-cell transformation (LCT)

• Significant nodal involvement (N3)

• Visceral involvement (M1)

• Relapsed or refractory disease after first-line systemic therapy (excluding methotrexate, retinoids, and interferon)

• Elevated serum LDH at diagnosis

• CLIC high-risk group: Stage IV disease, age >60, LCT, elevated LDH (≥2 risk factors)

  1. ISCL International Society for Cutaneous Lymphomas, EORTC European Organisation for Research and Treatment of Cancer, LDH lactate dehydrogenase, CLIC Cutaneous Lymphoma International Consortium.
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