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Stroma AReactive Invasion Front Areas (SARIFA) and the tumour immune microenvironment in colorectal cancer

British Journal of Cancer volume 132, pages 983–985 (2025)Cite this article

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This is a reply to Tapiainen et al.:

Tapiainen, V.V., Sirniö, P., Elomaa, H. et al. Stroma AReactive Invasion Front Areas (SARIFA), tumour immune microenvironment, and survival in colorectal cancer. Br J Cancer (2025). https://doi.org/10.1038/s41416-025-02972-z.

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Fig. 1: SARIFA-positivity, which is defined as direct tumor-adipocyte interaction at the invasion front, is associated with an aggressive course of disease and an altered immunity in colorectal cancer.

References

  1. Tapiainen VV, Sirniö P, Elomaa H, Karjalainen H, Äijälä VK, Kastinen M, et al. Stroma AReactive Invasion Front Areas (SARIFA), tumour immune microenvironment, and survival in colorectal cancer. Br J Cancer. 2025. https://doi.org/10.1038/s41416-025-02972-z.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Reitsam NG, Grozdanov V, Löffler CML, Muti HS, Grosser B, Kather JN, et al. Novel biomarker SARIFA in colorectal cancer: highly prognostic, not genetically driven and histologic indicator of a distinct tumor biology. Cancer Gene Ther. 2024;31:207–16. https://doi.org/10.1038/s41417-023-00695-y.

    Article  CAS  PubMed  Google Scholar 

  3. Reitsam NG, Grosser B, Enke JS, Mueller W, Westwood A, West NP, et al. Stroma AReactive Invasion Front Areas (SARIFA): a novel histopathologic biomarker in colorectal cancer patients and its association with the luminal tumour proportion. Transl Oncol. 2024;44:101913. https://doi.org/10.1016/j.tranon.2024.101913.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Offermans K, Reitsam NG, Simons CCJM, Grosser B, Zimmermann J, Grabsch HI, et al. The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients. Cancer Metab. 2024;12:21. https://doi.org/10.1186/s40170-024-00349-z.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Martin B, Grosser B, Kempkens L, Miller S, Bauer S, Dhillon C, et al. Stroma areactive invasion front areas (SARIFA)—A new easily to determine biomarker in colon cancer—results of a retrospective study. Cancers. 2021;13: https://doi.org/10.3390/cancers13194880.

  6. Reitsam NG, Märkl B, Dintner S, Sipos E, Grochowski P, Grosser B, et al. Alterations in Natural Killer Cells in Colorectal Cancer Patients with Stroma AReactive Invasion Front Areas (SARIFA). Cancers. 2023;15: https://doi.org/10.3390/cancers15030994.

  7. Grosser B, Heyer CM, Austgen J, Sipos E, Reitsam NG, Hauser A, et al. Stroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor-adipocyte interaction indicating an altered immune response. Gastric Cancer. 2024;27, https://doi.org/10.1007/S10120-023-01436-8.

  8. Wala J, de Bruijn I, Coy S, Gagné A, Chan S, Chen Y-A, et al. Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers. bioRxiv. 2024. https://doi.org/10.1101/2024.09.24.614701.

  9. Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6, https://doi.org/10.1126/scisignal.2004088.

  10. Frei AL, McGuigan A, Sinha RRAK, Jabbar F, Gneo L, Tomasevic T, et al. Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II-III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis. Lancet Oncol. 2024;25:198–211. https://doi.org/10.1016/S1470-2045(23)00560-0.

    Article  PubMed  Google Scholar 

  11. Märkl B, Paul B, Schaller T, Kretsinger H, Kriening B, Schenkirsch G. The role of lymph node size and FOXP3+ regulatory T cells in node-negative colon cancer. J Clin Pathol. 2017;70: https://doi.org/10.1136/jclinpath-2016-203978.

  12. Grosser B, Glückstein MI, Dhillon C, Schiele S, Dintner S, VanSchoiack A, et al. Stroma AReactive Invasion Front Areas (SARIFA) – a new prognostic biomarker in gastric cancer related to tumor-promoting adipocytes. J Pathol. 2022;256: https://doi.org/10.1002/path.5810.

  13. Grochowski P, Grosser B, Sommer F, Probst A, Waidhauser J, Schenkirsch G, et al. The Concept of Stroma AReactive Invasion Front Areas (SARIFA) as a new prognostic biomarker for lipid-driven cancers holds true in pancreatic ductal adenocarcinoma. BMC Cancer. 2024;24:768. https://doi.org/10.1186/s12885-024-12519-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank Wala et al. [8] for making their genomic and spatial profiling data publicly available via cBioPortal [9].

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Authors and Affiliations

  1. Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany

    Nic G. Reitsam & Bruno Märkl

  2. Bavarian Cancer Research Center (BZKF), Augsburg, Germany

    Nic G. Reitsam & Bruno Märkl

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  1. Nic G. Reitsam
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  2. Bruno Märkl
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NGR and BM conceived the study. NGR performed data analysis. BM and NGR interpreted the data and wrote the manuscript.

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Correspondence to Nic G. Reitsam.

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Reitsam, N.G., Märkl, B. Stroma AReactive Invasion Front Areas (SARIFA) and the tumour immune microenvironment in colorectal cancer. Br J Cancer 132, 983–985 (2025). https://doi.org/10.1038/s41416-025-03034-0

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