Fig. 6: Effect of Nrf2 overexpression on Ara-C chemotherapy resistance in vivo. | Cancer Gene Therapy

Fig. 6: Effect of Nrf2 overexpression on Ara-C chemotherapy resistance in vivo.

From: RETRACTED ARTICLE: Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4

Fig. 6

The mice were randomized in 4 groups (EV1 (n = 4), L-Nrf2 (n = 4), EV1 + Ara-C (n = 4), L-Nrf2+Ara-C (n = 4). After successful xenotransplantation, the mice were treated with Ara-C (60 mg/kg/day, a week) for one week, all mice were sacrificed after 37 days. EV, empty vector, Ara-C, cytarabine. L-Nrf2, overexpressed Nrf2. siNrf2, silenced Nrf2. A Representative images of tumor growth were photographed. B Images of tumors extracted and photographed in mice. C Tumor weight change curve of xenotransplantation mice. D Tumor volume change curve of xenotransplantation mice. E Survival curves of xenograft mice were plotted by Kaplan–Meier method. F, G The expression of Nrf2 and RFC4 in tumor tissues of xenograft mice were investigated by immunohistochemistry (scale bars: 100 and 50 μm from left to right). Results represented the mean ± SD from 3 separate assays. ***P < 0.001, **P < 0.01, *P < 0.05.

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