Fig. 1: Splicing, RNA exosome and Nonsense-mediated decay machineries dysregulation in PMP. | Cancer Gene Therapy

Fig. 1: Splicing, RNA exosome and Nonsense-mediated decay machineries dysregulation in PMP.

From: Exploring RNA biology in pseudomyxoma peritonei uncovers splicing dysregulation as a novel, targetable molecular vulnerability

Fig. 1

A RNA expression level of each machinery individually as Log2 of the Fold-Change Tumor/Control. In the upper panel the expression of all genes is represented showing upregulated (colored in red) and downregulated genes (colored in blue) as the Log2 of the Fold-Change of Tumor/Control (n = 11 controls; n = 18 tumors); in the graph below are represented the statistically significant genes altered as violin plots as Log2 of normalized copy number, showing the median expression and the first and third quartiles (thin lines). T-test or Mann–Whitney U test were used to compare means between the two groups. Asterisks represent significant differences: *p < 0.05; **p < 0.01; ****p < 0.0001. B PLS-DA and VIP-Score of all significantly altered genes. PLS-DA shows two different clusters: control tissue (“0”, green) and PMP tissue (“1”, red); in the right panel is the score of each of these genes (top 15) contribution to the discrimination model, VIP-Score, and the mean expression of each gene in the control, “0”, and PMP, “1”, groups (“high expression” in red, “low expression” in blue).

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