Fig. 4: Cell cycle and proliferation, immunomodulation and inflammation and angiogenesis genes expression in PMP and its association to splicing genes expression. | Cancer Gene Therapy

Fig. 4: Cell cycle and proliferation, immunomodulation and inflammation and angiogenesis genes expression in PMP and its association to splicing genes expression.

From: Exploring RNA biology in pseudomyxoma peritonei uncovers splicing dysregulation as a novel, targetable molecular vulnerability

Fig. 4

A Significantly altered cancer-related genes in PMP. CDKN2A, CDKN2D, CDK4, CDK6, ATM, CXCL3, CCL5, CXCR2 and KDR expression are represented as Log2 of normalized copy number in the control (white violin, n = 11) and the PMP (colored violin, n = 18) tissues. T-test or Mann–Whitney U test were used and asterisks represent significant differences: *p < 0.05; **p < 0.01; *** p < 0.001. B Significant correlations found between these cancer-related altered genes and splicing-related dysregulated genes. Significant correlations are shown together with Pearson or Spearman correlation coefficient (r) and p value in each case.

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