Fig. 3: Identification of IRF4-related immunophenotypes and its relationship with STING. | Cancer Gene Therapy

Fig. 3: Identification of IRF4-related immunophenotypes and its relationship with STING.

From: Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma

Fig. 3

A Characterization of B cells with IRF4 expression in the single-cell sequencing dataset GSE160269. B Association between IRF4 and B cell subtypes within the TLS-enriched samples in the single-cell sequencing dataset GSE160269. C Positive correlation between IRF4 gene expression and activated B cell infiltration. D Immune infiltration patterns of ESCC stratified by IRF4 expression levels in the GEO dataset GSE53625. E Immune infiltration pattern of ESCC stratified by IRF4 expression levels in 41 surgical specimens from our internal cohort. F Enrichment of IRF4 and STING in the NF-κB pathway. G Relationship between IRF4 and STING expression levels.

Back to article page