Fig. 4: Impact of CD40 stimulation on the expression of IRF4 and B cell differentiation in ESCC. | Cancer Gene Therapy

Fig. 4: Impact of CD40 stimulation on the expression of IRF4 and B cell differentiation in ESCC.

From: Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma

Fig. 4

A, B Impact of CD40 stimulation on expression of IRF4 in B cells under different ESCC-CM (n = 3). C Impact of CD40 stimulation on the inhibitory effect of B cells on tumor cell proliferation (n = 3). D Flow cytometric analysis indicated that CD40 stimulation altered the degree of B cell differentiation (APC-CD19, PE-pre-BCR). E The effect of CD40 stimulation on the production of TLS-related chemokines in B cells under TE-1 and EC109 CM (n = 3). CM conditioned medium. *p < 0.05; **p < 0.01; ***p < 0.0001.

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