Fig. 1: The general properties of IL-7 cytokine.
From: Promoting the therapeutic potential of interleukin-7 (IL-7) by expression in viral vectors
IL-7 helps in organogenesis (e.g., lymph nodes), T-cell development centrally in thymus, survival and homeostasis of natural killer (NK) and tumor-infiltrating T cells (TILs), and development, maturation, and homeostasis of B lymphocytes. IL-7 also enhances infiltration and proliferation of cytotoxic T cells into the tumor microenvironment and prevents T-cell exhaustion by reducing programmed death 1 (PD-1) expression on TILs.
