Fig. 3: scRNA-Seq analysis of CAC cells in mice with myeloid-specific deletion of Mir34a. | Cell Death & Differentiation

Fig. 3: scRNA-Seq analysis of CAC cells in mice with myeloid-specific deletion of Mir34a.

From: Myeloid Mir34a suppresses colitis-associated colon cancer: characterization of mediators by single-cell RNA sequencing

Fig. 3

A UMAP plot showing subtypes of tumor epithelial cells from CACs, derived from Mir34aΔMye and Mir34aF/F mice. B Heatmap of top ten differentially expressed genes in each tumor epithelial cell subtype. C Proportions of tumor epithelial cell subtypes in Mir34aΔMye and Mir34aF/F CACs. D Enrichment of indicated MsigDB Hallmark gene sets in differentially expressed genes for each tumor epithelial cell subtype. E UMAP plots of tumor epithelial cells colored by the expression of indicated mRNAs. F Expression of indicated EMT-related mRNAs in Mir34aΔMye and Mir34aF/F tumor epithelial cells. G UMAP plots of tumor epithelial cells colored by the expression of indicated EMT-related mRNAs. Significance was determined as described in the methods section scRNA-Seq data analysis (p < 0.001***). The mRNAs not marked with asterices did not reach significance in their differential expression.

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