Fig. 7: Working model for the function of LDHB in ferroptosis surveillance.
From: Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer
LDHB noncanonically protects KRAS-driven lung cancer from ferroptosis by promoting the SLC7A11/GSH axis. LDHB blockade is synthetic lethal with SLC7A11 inhibitors due to hyperactivation of glutamine metabolism and mitoROS-dependent ferroptosis.
