Fig. 5: Gasdermins are a transkingdom family of pore-forming proteins controlling immune cell death.
From: Regulated cell death in fungi from a comparative immunology perspective
A Shown are cartoon representations of gasdermin pores with known structures. The two allelic variants RCD-1-1 and RCD-1-2 from N. crassa are currently the only known gasdermins to form heteromeric pores, composed of eleven alternating RCD-1-1/RCD-1-2 dimers. The RCD-1 fGSDM is not controlled by proteolytic cleavage, like most other gasdermins, but by the coexistance in the same cell of the two allelic variants. This coexistance occurs only when N. crassa strains from the rcd-1-1 and rcd-1-2 antagonistic genotypes undergo cellular fusion. B The majority of gasdermins in microorganisms (bacteria and fungi) are genomically clustered with protease-encoding genes. These multidomain proteases are putative molecular sensors that control the adjecently encoded gasdermin. PDB IDs: GSDMD (6VFE), GSDMA3 (6CB8), TrichoGSDM (8JYW), bGSDM (8SL0), fGSDM (8JYZ).
