Fig. 4: The spatial distribution of stromal regions affects the gene expression of IMPC regions in sample 1.

A The spatial distribution position of two stromal clusters (cluster 0 and 2). The stroma (green cluster) is far from IMPC regions (blue and pink clusters). Another stroma (red cluster) is near IMPC regions. B–E The expression level of IGKC, IGHG4, IGHG3, and IGHA1 genes on the spatial plots. F, G The enrichment results of cluster 0 highly expressed top 50 genes on GO (BP) and KEGG. H, I The enrichment results of cluster 2 highly expressed top 50 genes on GO (BP), and KEGG. The arrows represent that these terms were linked to immune response, cellular interaction, complement pathway, and oxidative phosphorylation, etc.