Fig. 3: RhoA in cardiomyocytes provides protection against pressure overload by regulation of compensatory hypertrophy and inhibition of cardiac dysfunction but enhances fibrosis. | Cell Death & Disease

Fig. 3: RhoA in cardiomyocytes provides protection against pressure overload by regulation of compensatory hypertrophy and inhibition of cardiac dysfunction but enhances fibrosis.

From: Untangling the role of RhoA in the heart: protective effect and mechanism

Fig. 3

RhoA is activated in response to pressure overload and contributes to the development of compensatory hypertrophy and protects the heart against cardiac dilation and contractile dysfunction. The protective effects of RhoA are mediated by YAP, ROCK1, and MRTF-A-mDia pathways. However, RhoA facilitates cardiac fibrosis possibly through activation of ROCK2 and MRTF-A.

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