Fig. 4: RhoA in cardiomyocytes preserves mitochondrial integrity and provides protection against ischemic stress. | Cell Death & Disease

Fig. 4: RhoA in cardiomyocytes preserves mitochondrial integrity and provides protection against ischemic stress.

From: Untangling the role of RhoA in the heart: protective effect and mechanism

Fig. 4

RhoA is activated by ischemic stress and engages multiple downstream molecules such as YAP, ROCK, MRTF-A and PLCε to activate protective kinase Akt, ERK and PKD, leading to inhibition of mitochondrial death pathways. RhoA also increases mitochondrial fission through regulation of Drp1 and enhances mitophagy through inhibition of PINK1 protein degradation to control mitochondrial quality in the ischemic heart.

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