Fig. 5: RhoA signaling regulates PINK1/Parkin-mediated mitophagy to preserve mitochondrial integrity.
From: Untangling the role of RhoA in the heart: protective effect and mechanism
PINK1 protein stability is regulated by the molecular interaction of RhoA with PINK1. Parkin expression is transcriptionally regulated by ROCK through inhibition of N-Myc as well as YAP.
