Fig. 8: Chromatin assembly analysis in UMSCC1 and UM-Cis cells. | Cell Death & Disease

Fig. 8: Chromatin assembly analysis in UMSCC1 and UM-Cis cells.

From: Chromatin remodeling-driven autophagy activation induces cisplatin resistance in oral squamous cell carcinoma

Fig. 8

A, B qPCR data showing the chromatin accessibility of specific genes’ region in UMSCC1 and UM-Cis cells. The lower Ct shift suggests more condensed chromatin conformations. C qPCR data showing the chromatin accessibility of autophagy-associated promoter regions. D qPCR data showing the chromatin accessibility of autophagy-associated promoter regions after transfection of UM-Cis cells with siHIST3H2A or siHIST3H2B. Results represent the mean ± standard deviation of three independent experiments (*p < 0.05, **p < 0.01, ***p < 0.005). E Schematic representation of the molecular mechanism exerting the cisplatin resistance in UM-Cis cells via the interplay between histone proteins and autophagy.

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