Fig. 2: Gasdermins are downstream effector of caspase 8 in TAK1 inhibition-induced mitochondrial ROS. | Cell Death & Disease

Fig. 2: Gasdermins are downstream effector of caspase 8 in TAK1 inhibition-induced mitochondrial ROS.

From: TAK1 inhibition activates pore-forming proteins to block intracellular bacterial growth through modulating mitochondria

Fig. 2

A, B BMDMs isolated from the indicated genotypes were treated with 300 nM 5ZOZ for 18 h. Representative MitoSox analysis in live BMDMs is shown (A). Median fluorescence intensity (MFI) in live BMDMs relative to vehicle treated BMDMs is shown (B). One-way ANOVA, multiple comparisons, Tukey test; *, p < 0.05.

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